Novel pyrazinone and pyridinone thrombin inhibitors incorporating weakly basic heterobicyclic P1-arginine mimetics

DOI: 10.1016/j.ejmech.2005.03.007

Source and publish data:

European Journal of Medicinal Chemistry p. 782 - 791 (2005)

Update date:2022-09-26

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Authors:

Kranjc, Andreja

Masic, Lucija Peterlin

Reven, Sebastjan

Mikic, Klemen

Prezelj, Andrej

Stegnar, Mojca

Kikelj, Danijel

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Article abstract of DOI:10.1016/j.ejmech.2005.03.007

The design, synthesis and biological activity of new thrombin inhibitors with a pyridinone or pyrazinone core and different heterobicyclic P₁ arginine side-chain mimetics are described. The arginine side-chain mimetics used in this study are (±

Full text of DOI:10.1016/j.ejmech.2005.03.007

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