Discovery of hydroxamic acid analogs as dual inhibitors of phosphodiesterase-1 and -5

DOI: 10.1016/j.bmcl.2005.06.016

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4085 - 4090 (2005)

Update date:2022-08-03

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Authors:

Dan, Akihito

Shiyama, Takaaki

Yamazaki, Kazuto

Kusunose, Naoto

Fujita, Katsuya

Sato, Hideshi

Matsui, Kazutaka

Kitano, Masafumi

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Article abstract of DOI:10.1016/j.bmcl.2005.06.016

HTS and the following synthesis of a series of the compounds led us to the discovery of hydroxamic acid analogs as potent dual inhibitors of phosphodiesterase (PDE)-1 and 5. These compounds have highly related structure and deviation of the structure usua

Full text of DOI:10.1016/j.bmcl.2005.06.016

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