New aminopyrimidine derivatives as inhibitors of the TAM family

DOI: 10.1016/j.ejmech.2013.10.037

Source and publish data:

European Journal of Medicinal Chemistry p. 789 - 801 (2013)

Update date:2022-07-30

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Authors:

Traoré, Ténin

Cavagnino, Andrea

Saettel, Nicolas

Radvanyi, Fran?ois

Piguel, Sandrine

Bernard-Pierrot, Isabelle

Stoven, Véronique

Legraverend, Michel

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Article abstract of DOI:10.1016/j.ejmech.2013.10.037

In this study, we describe the synthesis of new pyrimidine analogs of BMS-777607, a potent and selective inhibitor of Met kinase. Inhibition of Met and Axl remained high whereas inhibition of Tyro3 and Mer decreased to some extend. The preferential modera

Full text of DOI:10.1016/j.ejmech.2013.10.037

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