Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors

DOI: 10.1016/j.bmcl.2006.07.061

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5373 - 5377 (2006)

Update date:2022-08-03

Topics:

Authors:

Xu, Jinyou

Wei, Lan

Mathvink, Robert J.

Edmondson, Scott D.

Eiermann, George J.

He, Huaibing

Leone, Joseph F.

Leiting, Barbara

Lyons, Kathryn A.

Marsilio, Frank

Patel, Reshma A.

Patel, Sangita B.

Petrov, Aleksandr

Scapin, Giovanna

Wu, Joseph K.

Thornberry, Nancy A.

Weber, Ann E.

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Article abstract of DOI:10.1016/j.bmcl.2006.07.061

A novel series of oxadiazole based amides have been shown to be potent DPP-4 inhibitors. The optimized compound 43 exhibited excellent selectivity over a variety of DPP-4 homologs.

Full text of DOI:10.1016/j.bmcl.2006.07.061

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