Bioorganic and Medicinal Chemistry Letters p. 1725 - 1729 (2008)
Update date:2022-08-05
Topics: Optimization CB2 receptor Agonists Arylsulfonamide SAR (Structure-Activity Relationship)
Ermann, Monika
Riether, Doris
Walker, Edward R.
Mushi, Innocent F.
Jenkins, James E.
Noya-Marino, Beatriz
Brewer, Mark L.
Taylor, Malcolm G.
Amouzegh, Patricia
East, Stephen P.
Dymock, Brian W.
Gemkow, Mark J.
Kahrs, Andreas F.
Ebneth, Andreas
Loebbe, Sabine
O'Shea, Kathy
Shih, Daw-Tsun
Thomson, David
A high-throughput screening campaign resulted in the discovery of a highly potent dual cannabinoid receptor 1 (CB1) and 2 (CB2) agonist. Following a thorough SAR exploration, a series of selective CB2 full agonists were identified.
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