Tetracyclic Chromophoric Analogues of Actinomycin D: Synthesis, Structure Elucidation and Interconvertibility from One Form to Another, Antitumor Activity, and Structure-Activity Relationships

Article abstract of DOI:10.1021/jm00365a015

Two different tetracyclic chromophoric analogues of actinomycin D have been synthesized by engaging two chromophoric DNA-binding functions in actinomycin D, i.e., 2-amino and 3-oxo, into either a 1,4-oxazin-2-one or an oxazole ring system.A third analogue