Journal of Organic Chemistry p. 3960 - 3966 (1983)
Update date:2022-08-02
Topics:
Wilson, William K.
Baca, Shawn B.
Barber, Yolanda J.
Scallen, Terence J.
Morrow, Cary J.
Pig liver esterase has been shown to stereoselectively hydrolyze the R enantiomer of several chiral 3-hydroxy-3-methylalkanoic acid esters of the form RC(Me)(OH)CH2COOR', where R = Et, CH2=CHCH2, Me(CH2)5, (MeO)2CHCH2, and PhCH2OCH2CH2 and R'= Me or Et.The unhydrolyzed ester and the reesterified carboxylic acid were analyzed for enantiomeric purity by NMR using the chiral shift reagent Eu(hfc)3.For the compounds studied, the S enantiomers consistently showed greater induced shifts.Products of the resolution are potential intermediates in the preparation of compactin analogues having defined stereochemistry at carbon-3.These analogues will be useful in testing the hypothesis that the hypocholesterolemic activity of compactin and its analogues resides in their ability to mimic the binding of mevaldic acid coenzyme A hemithioacetal to HMG-CoA reductase but not be reduced to mevalonate.
View MoreChangzhou Hopschain Chemical Co.,Ltd
Contact:86-519-85528066
Address:Room 710, Unit A, Xingbei Development Mansion, Tongjiang Road, Changzhou City,213000, China
Zhejiang Genebest Pharmaceutical Co.,Ltd.
Contact:0086-571-63532866
Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Wuhan Shangrisyn chemicals Technology Co.,Ltd(expird)
Contact:+86-027-84466317 __ +86-15387123698
Address:wuhan - china
Changzhou Kingyo Chemical Corporation Ltd.
website:http://www.kingyochem.com
Contact:+86-519-85105717
Address:19# Wuqing North Road, Changzhou , Jiangsu, China
Shenyang Xingzhenghe Chemical Co., Ltd.
Contact:024-23509232
Address:No. 33, Naner Road, Heping Dist.
Doi:10.1016/j.tetlet.2018.12.011
(2019)Doi:10.1016/S0960-894X(99)00546-6
(1999)Doi:10.1007/s000180050076
(1997)Doi:10.1039/a907284e
(1999)Doi:10.1021/acs.inorgchem.8b01313
(2018)Doi:10.1021/ja9802448
(1998)