Bioorganic and Medicinal Chemistry Letters p. 36 - 39 (2006)
Update date:2022-08-05
Topics:
Yin, Zheng
Patel, Sejal J.
Wang, Wei-Ling
Wang, Gang
Chan, Wai-Ling
Rao, K.R. Ranga
Alam, Jenefer
Jeyaraj, Duraiswamy A.
Ngew, Xinyi
Patel, Viral
Beer, David
Lim, Siew Pheng
Vasudevan, Subhash G.
Keller, Thomas H.
Substrate-based tetrapeptide inhibitors with various warheads were designed, synthesized, and evaluated against the Dengue virus NS3 protease. Effective inhibition was achieved by peptide inhibitors with electrophilic warheads such as aldehyde, trifluorom
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