Journal of Medicinal Chemistry p. 1772 - 1775 (1983)
Update date:2022-08-03
Atkinson, Edward R.
McRitchie-Ticknor, Donna D.
Harris, Louis S.
Archer, Sydney
Aceto, Mario D.
et al.
The 19 esters in Table I were prepared from (+)-2α-tropanol, (-)-2β-tropanol, (+/-)-3-quinuclidinol, and a variety of non-glycolic acids in order to compare their central and pheripheral activities with those of the glycolates reported in the previous paper.The results (Table II) showed that esters 6 and 17 were approximately equivalent to one another and the atropine, that 8 was equal in both central and peripheral activity to reference glycolates, that 9 and 19 were less active than 8 but 9 had a substantially reduced central activity, and that 10 and 11 weremore active than the methoxy analogue reported earlier.
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