Parasympatholytic (Anticholinergic) Esters of the Isomeric 2-Tropanols. 2. Non-Glycolates

Article abstract of DOI:10.1021/jm00366a023

The 19 esters in Table I were prepared from (+)-2α-tropanol, (-)-2β-tropanol, (+/-)-3-quinuclidinol, and a variety of non-glycolic acids in order to compare their central and pheripheral activities with those of the glycolates reported in the previous paper.The results (Table II) showed that esters 6 and 17 were approximately equivalent to one another and the atropine, that 8 was equal in both central and peripheral activity to reference glycolates, that 9 and 19 were less active than 8 but 9 had a substantially reduced central activity, and that 10 and 11 weremore active than the methoxy analogue reported earlier.