One-pot and catalyst-free synthesis of thiosemicarbazones via multicomponent coupling reactions

Article abstract of DOI:10.1016/j.tetlet.2009.02.134

A novel and efficient procedure for the synthesis of thiosemicarbazones has been achieved via a multicomponent and catalyst-free reaction of phenyl or p-chlorophenyl isothiocyanate, hydrazine, and aldehydes or ketones. The method afforded 20 thiosemicarba