Tetrahedron p. 409 - 416 (1986)
Update date:2022-07-30
Topics:
Largeron, M.
Fleury, D.
Fleury, M. B.
In slightly basic aqueous-ethanol medium or in acetonitrile, electrochemical reduction of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (OLTIPRAZ 35972 R.P., antischistosomal drug) affords a convenient route to pyrrolo<1,2-a>pyrazine derivatives, which are found as metabolites of the drug in host urine.A transient species in the reduction process which is endowed with schistosomicidal activity is isolated.
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Doi:10.1016/S0022-328X(00)83115-0
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