Bioorganic and Medicinal Chemistry Letters p. 1643 - 1646 (2006)
Update date:2022-08-04
Topics:
Smith II, Leon
Piatnitski, Evgueni L.
Kiselyov, Alexander S.
Ouyang, Xiaohu
Chen, Xiaoling
Burdzovic-Wizemann, Sabina
Xu, Yongjiang
Wang, Ying
Rosler, Robin L.
Patel, Sheetal N.
Chiang, Hui-Hsien
Milligan, Daniel L.
Columbus, John
Wong, Wai C.
Doody, Jacqueline F.
Hadari, Yaron R.
A novel class of pyrimido[4,5-b]-1,4-benzoxazepines is described as inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase. Two compounds display potent EGFR inhibitory activity of less than 1 μM in cellular phosphorylation assays (IC50 0.47-0.69 μM) and are highly selective against a small kinase panel. Such compounds demonstrate anti-EGFR activity within a class that is different from any known EGFR inhibitor scaffolds. They also provide a basis for the design of kinase inhibitors with the desired selectivity profile.
View MoreHebei Kangtai Pharmaceutical Co.,Ltd
Contact:+86-0317-3512963
Address:Wugang Road,Mengcun of Cangzhou City,Hebei Province ,China
Shanghai Yuking Water Soluble Material Tech Co., Ltd
Contact:86-21-68286299
Address:4F, 13B, No. 600, South Xinyuan Road 201306, Shanghai, China
SHAANXI FUJIE PHARMACEUTICAL CO.,LTD
website:http://www.fujiepharm.com
Contact:+86-29-63650906
Address:Yuanqu Yi Road, Qinghe Food Industrial Park, Sanyuan County, Shaanxi Province, China
Yuan Shi(SuQian)Biotechnology Co.,Ltd
website:http://www.yuanshibio.com
Contact:+86-527-84226672
Address:jiangsu suqian
Shanghai PuYi Chem-Tech Co.,Ltd.
Contact:+86-21-57687505-227
Address:3 Floor, Building 11, No 201 MinYi Road, Songjiang District, Shanghai 201612, China
Doi:10.1002/mrc.1260251113
(1987)Doi:10.1081/NCN-59691
(2005)Doi:10.1039/c4cc04572f
(2014)Doi:10.1055/s-2005-918421
(2005)Doi:10.1021/jo00942a026
(1973)Doi:10.1139/v72-185
(1972)