cis-to-trans isomerization promoted by pyridine as a crucial step for the selective preparation of trans-Pt(SAr)(CI)(PAr′3)2

Article abstract of DOI:10.1021/ic051780l

The general strategy for the syntheses of trans-Pt(SAr)(CI) (PAr′₃)₂ (1) (Ar = Ph, C₆H ₄-2-Me, C₆H₄-3-OMe C₆H ₄-2-F, etc.; Ar′ = Ph, C₆H₄-4-OMe, C ₆H₄-4-Me, and C₆H₄-4-CF₃) by the reaction of cis-PtCl₂(PAr′₃)₂ with ArSH has been developed. The mechanistic investigation suggested that isomerization of cis-1 into trans-1 promoted by the combined use of C ₆H₆ as a solvent and pyridine as a base was the key to the successful preparation of 1.