Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription

DOI: 10.1021/jm00041a013

Source and publish data:

Journal of Medicinal Chemistry p. 2343 - 2351 (1994)

Update date:2022-07-30

Topics:

Authors:

Larsen Larsen

Spilman Spilman

Yagi Yagi

Dinh Dinh

Hart Hart

Hess Hess

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00041a013

The synthesis and biological activity of a series of seco-oxysterol analogs designed to be inhibitors of transcription of the gene for 3- hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGR) are described. The compound possessing the most significant acti

Full text of DOI:10.1021/jm00041a013

Products guided by the article

Product name:Cyclohexanecarboxylic acid, 4-hydroxy-1-methyl-, methyl ester, trans-

Cas No:87787-02-8

R&D Labs maybe for 87787-02-8

Xian Changyue Biological Technology Co., Ltd.

website:https://www.xachangyue.com/

Contact:+86-029-88211911

Address:Keji Road NO.70
SHENZHEN PENGCHENG REDSTAR INDUSTRY CO.,LTD

Contact:+86-755-82412922

Address:Room 8066, East Block, Square City, Jiabin Road, Luohu District
HANGZHOU TOYOND BIOTECH CO., LTD

Contact:+86-571-86965177

Address:No. 189, Fengqi East Road, Hangzhou, China
WEIFANG DERUN CHEMICAL CO.,LTD

Contact:86-536-8956886

Address:weifang
Hebei Maison Chemical Co.,Ltd

website:http://www.maisonchem.com.cn

Contact:0086-311-83833777

Address:Leitou industrial district, xinji, shijiazhuang city, hebei province,

Relevant to this article

Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic and antinociceptive properties

Doi:10.1021/jm00368a011
(1984)
DIE REAKTION VON HETERO-1,5-DIENEN MIT SCHWEFELDICHLORID - EINE SYNTHESE VON 2,3-DIHYDRO-1,4-BENZOTHIAZINEN

Doi:10.1016/S0040-4039(00)88135-6
(1983)
Carbene Reactions with Cis Azo Functions. Formation of Ester Azines from Δ³-1,3,4-Oxadiazolines

Doi:10.1021/jo00176a024
(1984)
Synthesis of spin-labeled analogues of drug molecules with potential action on neuroreceptors

Doi:10.1139/v83-437
(1983)
Asymmetric synthesis of the L-fuco-nojirimycin, a nanomolar α-L-fucosidase inhibitor

Doi:10.1016/j.bmcl.2005.11.100
(2006)
Grindstone chemistry: Protic ionic liquid-substrate tuned green synthesis of 1,2-disubstituted and 2-substituted benzimidazoles with outstanding selectivity

Doi:10.1039/c5ra08183a
(2015)

Article Doi