Design and synthesis of seco-oxysterol analogs as potential inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase gene transcription

DOI: 10.1021/jm00041a013

Source and publish data:

Journal of Medicinal Chemistry p. 2343 - 2351 (1994)

Update date:2022-07-30

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Authors:

Larsen Larsen

Spilman Spilman

Yagi Yagi

Dinh Dinh

Hart Hart

Hess Hess

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Article abstract of DOI:10.1021/jm00041a013

The synthesis and biological activity of a series of seco-oxysterol analogs designed to be inhibitors of transcription of the gene for 3- hydroxy-3-methylglutaryl-Coenzyme A reductase (HMGR) are described. The compound possessing the most significant acti

Full text of DOI:10.1021/jm00041a013

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