Titanocene(III) mediated 8-endo radical cyclizations for the synthesis of eight-membered cyclic ethers

Article abstract of DOI:10.1016/j.tetlet.2005.12.131

Titanocene(III) chloride (Cp₂TiCl) mediated 8-endo radical cyclizations towards the synthesis of eight-membered cyclic ethers have been described. Titanocene(III) chloride was prepared in situ from commercially available titanocene dichloride (Cp₂TiCl₂) and activated zinc dust in THF.