9,11-Epoxy-9-homoprosta-5-enoic acid analogues as thromboxane A2 receptor antagonists

DOI: 10.1021/jm00168a032

Source and publish data:

Journal of Medicinal Chemistry p. 1741 - 1748 (1990)

Update date:2022-08-04

Topics:

Authors:

Das Das

Hall Hall

Nakane Nakane

Haslanger

Reid Reid

Garber Garber

Truc Truc

Harris Harris

Hedberg Hedberg

Ogletree

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Article abstract of DOI:10.1021/jm00168a032

A novel bicyclic prostaglandin analogue, (1S)-[1α,2α(Z),3α(1E,3S*,4R*),4α]-7-[3-(3-hydroxy-4-phenyl-1-pen tenyl)-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid (4), was found to be a potent and selective thromboxane A₂ (TxA₂) recepto

Full text of DOI:10.1021/jm00168a032

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Product name:(Z)-7-[(1S,2R,3S,4R)-3-((E)-3-Cyclohexyl-3-oxo-propenyl)-7-oxa-bicyclo[2.2.1]hept-2-yl]-hept-5-enoic acid methyl ester

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