Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912: An O-analogue of the Pictet-Spengler reaction

Article abstract of DOI:10.1016/S0040-4039(99)00840-0

Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet- Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.