Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912: An O-analogue of the Pictet-Spengler reaction

DOI: 10.1016/S0040-4039(99)00840-0

Source and publish data:

Tetrahedron Letters p. 4917 - 4920 (1999)

Update date:2022-07-29

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Authors:

Albaneze-Walker

Rossen Rossen

Reamer Reamer

Volante Volante

Reider Reider

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Article abstract of DOI:10.1016/S0040-4039(99)00840-0

Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet- Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.

Full text of DOI:10.1016/S0040-4039(99)00840-0

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