Synthesis of benzofuroquinolizine for α-2 adrenoceptor antagonist MK- 912: An O-analogue of the Pictet-Spengler reaction

DOI: 10.1016/S0040-4039(99)00840-0

Source and publish data:

Tetrahedron Letters p. 4917 - 4920 (1999)

Update date:2022-07-29

Topics:

Authors:

Albaneze-Walker

Rossen Rossen

Reamer Reamer

Volante Volante

Reider Reider

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(99)00840-0

Efficient synthesis of benzofuroquinolizine ketone 1 was accomplished in four steps from ethyl 3-benzofuranacetate. The O-analogue of the Pictet- Spengler cyclization was used to form the benzofuroquinolizine ring structure as a key step.

Full text of DOI:10.1016/S0040-4039(99)00840-0

Products guided by the article

Product name:2-Butenoic acid, 4-(2-iodophenoxy)-, ethyl ester, (2E)-

Cas No:881015-10-7

R&D Labs maybe for 881015-10-7

puyang hongda shengdao new material co.,ltd.

Contact:+86-393- 4896278

Address:No.29 East Zhongyuan Road
Anhui Charm Imp.&Exp.Co., Ltd

website:http://www.chinacharm.cn/

Contact:86 551 5316260

Address:No. 211,XiangZhang Road,Hefei City,Anhui Province,China
Chengdu ZY Biochemical Technology Co., LTD

Contact:0086-28-88680086

Address:170 Qingpu Road, Shouan Town, Pujiang County
Shanggao Ruiya Fine Chemicals Co., Ltd

Contact:+86-795-2592103

Address:Xingguang Nanlu,Shanggao County Industry Park
HEBEI BRANT PHARMACEUTICAL

Contact:+86-0311-84455288-844

Address:Mayu Industrial Park, Jinzhou, Hebei, China.

Relevant to this article

Radical cyclisation of epoxynitrile-2-azetidinones mediated by Cp₂TiCl

Doi:10.1016/j.tet.2007.01.049
(2007)
Lewis Acid Coordination Redirects S-Nitrosothiol Signaling Output

Doi:10.1002/anie.202001450
()
SYNTHESIS OF SYMMETRICAL 1,2-DIHYDROTRIAZINES BY THE REACTION OF 1,1,1-TRIFLUORO-2-PHENYL-2,4,6,6-TETRACHLORO-3,5-DIAZAHEXA-3,5-DIENE WITH PRIMARY AMINES

Doi:10.1007/BF00506889
(1983)
An Efficient General Method for the Conversion of α-Quaternary Nitriles into Amides

Doi:10.1055/s-1983-30489
(1983)
Probes for narcotic receptor mediated phenomena. 4. Synthesis of (±)-2,3,4,5,6,6a-hexahydro-3-methyl-8-hydroxy-1H-4,11b-methanobenzofuro- [3,2-d]azocine, an oxide-bridged 5-(m-hydroxyphenyl)morphan

Doi:10.1021/jo00180a019
(1984)
Heterocyclic o-Quinodimethanes in Synthesis: A Diels-Alder Approach to Xanthene-Derived Heterocycles

Doi:10.1021/jo00046a043
(1992)

Article Doi