Helvetica Chimica Acta p. 1625 - 1629 (1984)
Update date:2022-08-05
Topics:
Grossen, Peter
Herold, Peter
Mohr, Peter
Tamm, Christoph
Two new syntheses of verrucarinic acid ((2S,3R)-2,5-dihydroxy-3-methylpentanoic acid) and its derivatives, suitably protected for the further conversion to macrocyclic trichothecenes, are described.The first one makes use of a diastereoselective alkylation of a (-)-(S)-malic acid ester and the regioselective reduction of one carboxyl function to a methyl group.The second approach involves a stereoselective addition of an allylsilane to a chiral glyoxylate.
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(1984)
