Synthesis of Tic-D-Phe Ψ[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists

DOI: 10.1016/j.bmcl.2005.12.005

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1721 - 1725 (2006)

Update date:2022-08-05

Topics: Deprotection Purification and characterization Activation of Carboxylic Acid Further Elaboration

Authors:

Tian, Xinrong

Chen, Xuemei

Gan, Lixian

Hayes, Jeffery C.

Switzer, Adrian G.

Solinsky, Mark G.

Ebetino, Frank H.

Wos, John A.

Pinney, Beth B.

Farmer, Julie A.

Crossdoersen, Doreen

Sheldon, Russell J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/j.bmcl.2005.12.005

The first synthesis of Tic-d-Phe Ψ[CH₂-CH₂] isostere is described, which features diastereoselective alkylation of the tricyclic lactam 14. The use of this novel dipeptide isostere in the development of melanocortin agonists has been

Full text of DOI:10.1016/j.bmcl.2005.12.005

Products guided by the article

Product name:(3R,11aR)-3-Benzyl-1,2,3,6,11,11a-hexahydro-pyrido[1,2-b]isoquinolin-4-one

Cas No:882172-39-6

R&D Labs maybe for 882172-39-6

Second Pharma Co., Ltd

Contact:+86-575-82733999 0575-82732999

Address:hangzhou gulf fine chemical zone,shangyu city,zhejiang province
SHANDONG CREDAGRI CHEMICAL CO., LTD.

Contact:+86-531-88872050

Address:ROOM 601A, BUILDING 2, SHUNTAI SQUARE, NO. 2000 SHUNHUA ROAD, HI-TECH DEVELOPMENT ZONE, JINAN, CHINA.
Nanjing Habo Medical Technology Co., Ltd.

Contact:025－85769882

Address:No.108. Ganjiabian east. Qixia District .Nanjing
Rudong Zhenfeng Yiyang Chemical Co., Ltd.

Contact:0513-84573047

Address:South Fengli Town, Rudong County, Jiangsu Province, China
Jiangsu Dacheng Pharmaceutical and Chemical Co.,Ltd

Contact:+86-0517-87036900

Address:Chuzhou Chemical park, Huai'an, Jiangsu Province

Relevant to this article

Cyclisation of α-(2-mercaptobenzoyl)- and α-(2-aminobenzoyl)lactames; Synthesis of benzothiopyranopyrrolinones and pyrrolinoquinolinones

Doi:10.1002/ardp.19833161102
(1983)
Design, synthesis, and biological evaluation of pyrimidine-2-carboxamide analogs: Investigation for novel RAGE inhibitors with reduced hydrophobicity and toxicity

Doi:10.1007/s12272-015-0596-5
(2015)
Preparative resolution of a key intermediate for the synthesis of optically active m-phenylene PGI₂ derivatives

Doi:10.1016/S0957-4166(99)00442-5
(1999)
Kinetic and thermodynamic aspects of the regioselective addition of bifunctional hydroxylaminooxime-type HO-nucleophiles to Pt-complexed nitriles

Doi:10.1021/ic051909r
(2006)
2-Benzazepines. 7. Synthesis of pyrimido[5,4-d][2]benzazepines [1]

Doi:10.1002/jhet.5570200512
(1983)
A new approach towards 2-amino-1-aryloxy-3-methoxypropanes from 1-arylmethyl-2-(bromomethyl)aziridines

Doi:10.1016/j.tet.2005.12.006
(2006)

Article Doi