Electroorganic Chemistry. 82. β-Amino Acid Esters from α-Methoxycarbamates and Ketene Silyl Acetals; Cyclization to β-Lactams

Article abstract of DOI:10.1021/jo00180a020

A new synthetic method of β-lactams 1'is described.The key intermediates, N-carbomethoxy-β-amino acid esters 2', were synthesized by the reaction of α-methoxylated carbamates 3' with ketene methyl trimethylsilyl acetals 4' catalyzed by titanium tetrachlor