Journal of Medicinal Chemistry p. 2318 - 2325 (1989)
Update date:2022-08-05
Topics:
DeVries, Vern G.
Bloom, Jonathan D.
Dutia, Minu D.
Katocs, Andrew S.
Largis, Elwood E.
The discovery that a series of N,N-dialkyl-N'-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic modification of three sites of the urea backbone.This study culminated in the selection of N'-(2,4-dimethylphenyl)-N-benzyl-N-n-butylurea (115) for more extensive biological evaluation.ACAT inhibitors are seen as potentially beneficial agents against hypercholesterolemia and atherosclerosis.
View MoreQINGDAO NEW FLOURISH INTERNATIOANAL TRADE CO., LTD.
Contact:+86 532 80861829
Address:No. 1, Yinchuan East Road, 266061, Qingdao, China
Jiaxing Carry Bio-Chem Technology Co.,Ltd
website:http://www.carrybiotech.com
Contact:0573-82788958
Address:Add.Fl 3th, Pharm Vally,Kaichuang Rd, Xiuzhou District, Jiaxing, Zhejiang,314031,China
Shanghai Jingshi Pharmaceutical Technology Co., Ltd.
Contact:13917643586
Address:shanghai
Chengdu Aslee Biopharmaceuticals, Inc
Contact:18608018419
Address:Chengdu Aslee Biopharmaceuticals, Inc
Changsha Kamer Essence and Flavor Co.,Ltd
Contact:86-731-89832270
Address:No.327 Kangnin Road Changsha Bio Information Industry Park, Changsha city, Hunan province
Doi:10.1021/jo052569u
(2006)Doi:10.1021/ic052091c
(2006)Doi:10.1016/j.bmc.2005.11.043
(2006)Doi:10.1016/S0022-328X(00)99299-4
(1983)Doi:10.1021/ic052158w
(2006)Doi:10.1021/jo0711539
(2007)
