Journal of Medicinal Chemistry p. 2318 - 2325 (1989)
Update date:2022-08-05
Topics:
DeVries, Vern G.
Bloom, Jonathan D.
Dutia, Minu D.
Katocs, Andrew S.
Largis, Elwood E.
The discovery that a series of N,N-dialkyl-N'-arylureas were inhibitors of the ACAT enzyme has led to a structure-activity study involving the systematic modification of three sites of the urea backbone.This study culminated in the selection of N'-(2,4-dimethylphenyl)-N-benzyl-N-n-butylurea (115) for more extensive biological evaluation.ACAT inhibitors are seen as potentially beneficial agents against hypercholesterolemia and atherosclerosis.
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