PYRIDINE ANNELATION OF o-METHYL ARYLCARBOXYLIC ACIDS WITH VILSMEIER REAGENTS

Article abstract of DOI:10.1016/S0040-4039(00)85968-7

The annelation of a pyridine ring by its c-position to pyridines, quinolines- and quinoxalines bearing ortho methyl and carboxylic acid groups occurs on treatment with Vilsmeier reagents; the reaction incorporates the nitrogen of the reagent.