Methotrexate Analogues. 21. Divergent Influence of Alkyl Chain Length on the Dihydrofolate Reductase Affinity and Cytotoxicity of Methotrexate Monoesters

DOI: 10.1021/jm00371a009

Source and publish data:

Journal of Medicinal Chemistry p. 605 - 609 (1984)

Update date:2022-08-04

Topics:

Authors:

Rosowsky, Andre

Forsch, Ronald A.

Yu, Cheng-Sein

Lazarus, Herbert

Beardsley, G. Peter

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00371a009

n-Octyl, n-dodecyl, and n-hexadecyl α- and γ-esters of methotrexate (MTX) were compared with the previously described α- and γ-n-butyl esters and with MTX as inhibitors of dihydrofolate reductase (DHFR) and human leukemic lymphoblasts (CEM cells) in cultu

Full text of DOI:10.1021/jm00371a009

Products guided by the article

Product name:L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-octyl ester

Cas No:88887-37-0

R&D Labs maybe for 88887-37-0

Guangzhou Shiny Co., Ltd.

Contact:+86-20-62802632;62802633

Address:Room 330 GIGCAS Building,No.511 Kehua Street,Tianhe District
JiangXi Hong Run Chemical Co., Ltd

Contact:+86-0791-88521351

Address:XingHuo industrial zone in YongXiu county
Hangzhou yi lu biont technology Co., LTD

Contact:+86-571-88152630

Address:Hangzhoushi HuafengRoad Yicheng3Building1001room.
Josun International Limited

website:http://www.josunpharma.com

Contact:+86-311-80715268 80766839

Address:No.39, Zhaiying Street, Shijaizhuang,Hebei,China
Ningbo Bichem Pharmaceutical Co.,Ltd

Contact:18957868060 057487816388

Address:ningbo

Relevant to this article

AN EFFICIENT SYNTHESIS OF SOME BIOLOGICALLY IMPORTANT MONOACYLATED DIAMINES

Doi:10.1016/S0040-4039(00)88399-9
(1983)
Synthesis of enantiomerically pure Sb-chirogenic organoantimony compounds and their crystal structures

Doi:10.1016/j.jorganchem.2005.10.042
(2006)
Optically Active 2-(Arylsulfinylmethyl)-oxazolines, Chiral Enol Acetate Equivalents in Aldol-Type Condensations

Doi:10.1055/s-1983-30607
(1983)
Photochemistry of Large Ring 2-Phenylcyclanones. Formation of Cyclophanes and Encapsulation by a Ship in Bottle and by a Reptation Strategy

Doi:10.1021/ja00269a051
(1986)
New stereodivergent approach to 3-amino-2,3,6-trideoxysugars. Enantioselective synthesis of daunosamine, ristosamine, acosamine, and epi-daunosamine

Doi:10.1021/ol034843h
(2003)
Azabicylcoalkanes as analgetics. II. An improved synthesis of 1 phenyl 6 azabicyclo[3,2,1]octane derivatives

Doi:10.1248/cpb.24.1514
(1976)

Article Doi