Methotrexate Analogues. 21. Divergent Influence of Alkyl Chain Length on the Dihydrofolate Reductase Affinity and Cytotoxicity of Methotrexate Monoesters

DOI: 10.1021/jm00371a009

Source and publish data:

Journal of Medicinal Chemistry p. 605 - 609 (1984)

Update date:2022-08-04

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Authors:

Rosowsky, Andre

Forsch, Ronald A.

Yu, Cheng-Sein

Lazarus, Herbert

Beardsley, G. Peter

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Article abstract of DOI:10.1021/jm00371a009

n-Octyl, n-dodecyl, and n-hexadecyl α- and γ-esters of methotrexate (MTX) were compared with the previously described α- and γ-n-butyl esters and with MTX as inhibitors of dihydrofolate reductase (DHFR) and human leukemic lymphoblasts (CEM cells) in cultu

Full text of DOI:10.1021/jm00371a009

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