Substituted Benzamides with Conformationally Restricted Side Chains. 2. Indolizine Derivatives as Central Dopamine Receptor Antagonists

DOI: 10.1021/jm00117a008

Source and publish data:

Journal of Medicinal Chemistry p. 1708 - 1712 (1988)

Update date:2022-08-04

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Authors:

King, Frank D.

Hadley, Michael S.

McClelland, Christine M.

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Article abstract of DOI:10.1021/jm00117a008

The substituted benzamides metoclopramide (1) and clebopride (3) are stimulants of gastric molitity.They are also central dopamine receptor antagonists with 3 being the more potent.This is presumed to be due to an additional interaction of its N-benzyl gr

Full text of DOI:10.1021/jm00117a008

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