Bioorganic and Medicinal Chemistry Letters p. 4994 - 5000 (2006)
Update date:2022-08-03
Topics:
Carpenter, Andrew J.
Al-Barazanji, Kamal A.
Barvian, Kevin K.
Bishop, Michael J.
Britt, Christy S.
Cooper, Joel P.
Goetz, Aaron S.
Grizzle, Mary K.
Hertzog, Donald L.
Ignar, Diane M.
Morgan, Ronda O.
Peckham, Gregory E.
Speake, Jason D.
Swain, Will R.
The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.
View MoreShanghai doly chemical Co.,Ltd
Contact:+86-21-34716221
Address:No.328,WuHe Roard,MinHang,ShangHai China
Xi'an yuanfar international trade company
website:https://www.yuanfarchemical.com
Contact:86-029-88745613 ext 828
Address:Floor19th ,B Building, Oak Block,No.36 South Fenghui Road, Dev. Zone of High-Tech Ind.,Xi’an, China
MedicalChem(Yancheng)Manuf.Co.,Ltd.
Contact:+86-515-84383366
Address:Touzeng BinHai, YanCheng City, JiangSu Province, China
Shanghai Egoal Chemical Co.,Ltd
Contact:+86-21-50333091
Address:Yangming Garden Square 3,YangGao North Road 1188, Pudong New District, Shanghai
Contact:+86+21-58956006 15800617331
Address:402 Room, 150# Cailun Road, Zhangjiang high tech park, Shanghai
Doi:10.1016/S0040-4039(01)01307-7
(2001)Doi:10.1016/j.bmcl.2016.09.049
(2016)Doi:10.1016/j.jorganchem.2013.09.015
(2014)Doi:10.1055/s-0035-1560449
(2016)Doi:10.1002/hlca.19710540845
(1971)Doi:10.1246/bcsj.45.2951
(1972)
