Bioorganic and Medicinal Chemistry Letters p. 4994 - 5000 (2006)
Update date:2022-08-03
Topics:
Carpenter, Andrew J.
Al-Barazanji, Kamal A.
Barvian, Kevin K.
Bishop, Michael J.
Britt, Christy S.
Cooper, Joel P.
Goetz, Aaron S.
Grizzle, Mary K.
Hertzog, Donald L.
Ignar, Diane M.
Morgan, Ronda O.
Peckham, Gregory E.
Speake, Jason D.
Swain, Will R.
The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.
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