A PRACTICAL METHOD FOR MULTIGRAM SCALE SYNTHESIS OF (+)-METHYL 5(S),6(R)-EPOXY-6-FORMYLHEXANOATE AND 2(R),3(S)-EPOXYOCTANAL, KEY INTERMEDIATES FOR SYNTHESIS OF LEUKOTRIENES A4

DOI: 10.1016/S0040-4039(00)85062-5

Source and publish data:

Tetrahedron Letters p. 4775 - 4778 (1986)

Update date:2022-08-03

Topics:

Authors:

Kobayashi, Yuichi

Kitano, Yasunori

Matsumoto, Takashi

Sato, Fumie

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Article abstract of DOI:10.1016/S0040-4039(00)85062-5

A practical method for multigram scale synthesis of (+)-methyl 5(S),6(R)-epoxy-6-formylhexanoate (1) and 2(R),3(S)-epoxyoctanal (13), key intermediates for synthesis of leukotrienes A₄, starting with (R)-glyceraldehyde acetonide (3) is described.

Full text of DOI:10.1016/S0040-4039(00)85062-5

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