Operationally convenient, efficient asymmetric synthesis of enantiomerically pure 4-aminoglutamic acids via methylene dimerization of chiral glycine equivalents with dichloromethane

DOI: 10.1016/j.tet.2006.04.023

Source and publish data:

Tetrahedron p. 6412 - 6419 (2006)

Update date:2022-09-26

Topics:

Authors:

Soloshonok, Vadim A.

Yamada, Takeshi

Ueki, Hisanori

Moore, Anna M.

Cook, Tanner K.

Arbogast, Kelsey L.

Soloshonok, Anatolii V.

Martin, Collin H.

Ohfune, Yasufumi

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Article abstract of DOI:10.1016/j.tet.2006.04.023

This paper presents a practical and efficient asymmetric synthesis of enantiomerically pure 4-aminoglutamic acids using a quite unusual methylene dimerization of chiral nucleophilic glycine equivalents with dichloromethane under phase-transfer catalysis (

Full text of DOI:10.1016/j.tet.2006.04.023

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