Journal of Medicinal Chemistry p. 806 - 810 (1984)
Update date:2022-08-04
Topics:
Guan, Ji-Hua
Neumeyer, John L.
Filer, Crist N.
Ahern, David G.
Lilly, Leslie
et al.
The synthesis of the title compounds (1c and its 2H isomer 1b) from N-(2-hydroxyethyl)norapomorphine was carried out by ring bromination, followed by chlorination to the 2-chloroethyl compound 6.Further reduction with 2H2 or 3H2 and Pd/C gave 1b or 1c.Radiochemically pure (97percent) 1c was obtained with a specific activity of 16.3 Ci/mmol.The purity of 1c was determined by LC, HPLC, UV, and NMR. <3H>NCA was shown to label the D2 receptor; however, the D2 signal appears to be only a small portion of the total signal, which may include binding to other dopamine receptor subtypes (D1 and D3).
View MoreTianjin Te-An Chemtech Co., Ltd.(expird)
Contact:+86-22-65378638
Address:A5-8, No.80 Haiyun Street, TEDA
website:http://www.apeptides.com/en/
Contact:+86-21-60871011
Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai
Yantai Derun Liquid Crystal Materials Co. Ltd.
website:http://www.ytderun.com
Contact:86-535-6300169
Address:ROOM 90, XIANGFU STREET, FUSHAN NEW-HIGH-TECH IDUSTRY ZONE, YANTAI
Zhejiang Kangfeng Chemical Co.,LTD.
Contact:+86-579-86709687
Address:Xueshizhai Industrial Zone, Weishan Town,Dongyang City, Zhejiang Province ,China
Shanghai agrotree chemical co.,ltd.
Contact:+86-21-50117563
Address:Room 8A,liangfeng building,No.8 dongfang RD.pudong,shanghai,China
Doi:10.1021/ja00869a018
(1962)Doi:10.1021/ja01170a050
(1949)Doi:10.1016/j.ejmech.2019.06.037
(2019)Doi:10.1002/anie.202103031
(2021)Doi:10.1002/anie.201001966
(2010)Doi:10.1016/j.tetlet.2018.01.056
(2018)