Synthetic studies of neoclerodane diterpenes from Salvia divinorum: Selective modification of the furan ring

Article abstract of DOI:10.1016/j.bmcl.2006.03.062

A synthetic sequence has been developed to selectively functionalize the furan ring of the natural product salvinorin A (2a). The synthetic routes described convert the furan ring in 2a into an N-sulfonylpyrrole, oxazole or an oxadiazole. In addition, a p