Bioorganic and Medicinal Chemistry Letters p. 1097 - 1101 (2011)
Update date:2022-08-05
Topics:
Wang, Zhao
Shi, Xuan-Hong
Wang, Jia
Zhou, Tian
Xu, You-Zhi
Huang, Ting-Ting
Li, Yan-Fang
Zhao, Ying-Lan
Yang, Li
Yang, Sheng-Yong
Yu, Luo-Ting
Wei, Yu-Quan
A series of novel benzothiazole-2-thiol derivatives were synthesized, and their anti-proliferative activities on HepG2 and MCF-7 cells were investigated. Most compounds had inhibitory effects on cell growth, and some of them were more effective than cisplatin. Compounds 6m and 6t displayed good inhibitory activities against a panel of different types of human cancer cell lines, with IC50 values in the low micromolar range. Further biological evaluation indicated that 6m induced apoptosis in HepG2 cancer cells. Structure-activity relationships were also proposed.
View MoreJiangxi Dongbang Pharmaceutical Co., Ltd.
Contact:+86-795-4433603, 4433388
Address:Fengxin Industrial Park, Fengxin County, Jiangxi Province, P.R.C
Hangzhou J&H Chemical Co., Ltd.
website:http://www.jhechem.com/
Contact:+86-571-87396432
Address:No.200 Zhenhua Rd.Xihu Industrial Park, Hangzhou 310030, China
Beijing Mediking Biopharm Co., Ltd.
Contact:+86-10-89753524/81760121/81769521
Address:Hongxianghong Incubator, Beiqijia Town, Changping district, Beijing, China
Jinan Jiaquan Chemical Co.,Ltd
Contact:+86-531-62318366
Address:Room 502 of Yidonghuayuan No.601 Huaxin Road Licheng District Jinan China
KAIYUAN CHEMICAL COMPANY LIMITED.
website:http://www.kaiyuanchem.com
Contact:+86-22-59891255/66/77
Address:B-2205, Kuangshi International Building, Yingbin Road, XiangLuo Bay Business District, Binhai New area, Tianjin, China.
Doi:10.1021/om060429k
(2006)Doi:10.1002/hlca.200690101
(2006)Doi:10.1002/hc.20435
(2008)Doi:10.1016/j.jorganchem.2006.03.021
(2006)Doi:10.1248/cpb.32.818
(1984)Doi:10.1135/cccc20051387
(2005)