Bioorganic and Medicinal Chemistry Letters p. 1097 - 1101 (2011)
Update date:2022-08-05
Topics:
Wang, Zhao
Shi, Xuan-Hong
Wang, Jia
Zhou, Tian
Xu, You-Zhi
Huang, Ting-Ting
Li, Yan-Fang
Zhao, Ying-Lan
Yang, Li
Yang, Sheng-Yong
Yu, Luo-Ting
Wei, Yu-Quan
A series of novel benzothiazole-2-thiol derivatives were synthesized, and their anti-proliferative activities on HepG2 and MCF-7 cells were investigated. Most compounds had inhibitory effects on cell growth, and some of them were more effective than cisplatin. Compounds 6m and 6t displayed good inhibitory activities against a panel of different types of human cancer cell lines, with IC50 values in the low micromolar range. Further biological evaluation indicated that 6m induced apoptosis in HepG2 cancer cells. Structure-activity relationships were also proposed.
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