A convenient synthesis of oxazolidinone derivatives linezolid and eperezolid from (S)-glyceraldehyde acetonide

DOI: 10.1002/hc.20435

Source and publish data:

Heteroatom Chemistry p. 316 - 319 (2008)

Update date:2022-08-05

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Authors:

Guangyu, Xu

Yi, Zhou

Chunhao, Yang

Yuyuan, Xie

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Article abstract of DOI:10.1002/hc.20435

A new convenient method for the synthesis of oxazolidinone antibacterials Linezolid and Eperezolid from readily available (S)-glyceraldehyde acetonide was developed. The key steps include reductive amination of arylamine and (S)-glyceraldehyde acetonide in the presence of NaBH₄ and 4 A sieve, followed by hydrolysis and regioselective cyclization.

Full text of DOI:10.1002/hc.20435

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