A reappraisal of the effect upon thymidine kinase of thymidine derivatives carrying large groups at the 5'-position

Article abstract of DOI:10.1021/jm00374a018

Several thymidine derivatives with hydrophobic 5'-substituents, linked by chemically stable amide and ether links, were synthesized as potential thymidine kinase inhibitors. None of these was active nor were several derivatives of thymidine 5'-acetate, wh