Solid-phase synthesis of hybrid thiazolidinedione-fatty acid PPARγ ligands

DOI: 10.1016/S0960-894X(97)10017-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2491 - 2496 (1997)

Update date:2022-08-05

Topics:

Authors:

Tomkinson, Nicholas C. O.

Sefler, Andrea M.

Plunket, Kelli D.

Blanchard, Steven G.

Parks, Derek J.

Willson, Timothy M.

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Article abstract of DOI:10.1016/S0960-894X(97)10017-8

A library of thiazolidinedione-fatty acid hybrid molecules was designed to probe the relationship between natural and synthetic PPAR ligands. Solid-phase synthesis of the library led to the identification of several high affinity PPARYγ ligands.

Full text of DOI:10.1016/S0960-894X(97)10017-8

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