Antitumor Imidazotetrazines. 14. Synthesis and Antitumor Activity of 6- and 8-Ssubstituted Imidazo-1,2,3,5-tetrazinones and 8-Substituted Pyrazolo-1,2,3,5-tetrazinones

Article abstract of DOI:10.1021/jm00385a018

The systematic variation of the potent antitumor agent mitozolomide (1) is extended to cover alteration of substituents at position 6 and 8 and to change the imidazo<5,1-d>-1,2,3,5-tetrazinone (6) skeleton to the isomeric pyrazolo<5,1-d>-1,2,3,5-tetrazino