European Journal of Medicinal Chemistry p. 531 - 535 (1989)
Update date:2022-09-26
Topics:
Gravier
Dupin
Casadebaig
Hou
Boisseau
Bernard
Some original 3-substituted 1,2,3,4-tetrahydroquinazolines were synthesized. Their antiplatelet activity was evaluated in vitro with respect to aggregation induced by the main inducers (ADP, collagen, arachidonic acid), platelet serotonin release reaction and thromboxane A2 synthesis. All these molecules possess an inhibiting power which, compared to that of aspirin in the same conditions, is the same or greater when aggregation is induced by ADP.
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