Journal of Medicinal Chemistry p. 1106 - 1109 (1985)
Update date:2022-08-03
Topics:
Groutas, William C.
Stanga, Michael A.
Brubaker, Michael J.
Huang, Tien L.
Moi, Min K.
Carroll, Robert T.
Several congeners of elasnin (I) have been synthesized and shown to inhibit human leukocyte elastase (HLE).The C-3 alkyl substituted 2-pyrones 11 and 12 were found to be most inhibitors of the enzyme.These compounds are highly specific in their inhibitory
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