Heterocyclic Analogues of Chlorcyclizine with Potent Hypolipidemic Activity

Article abstract of DOI:10.1021/jm00376a002

A series of <α-(heterocyclyl)benzyl>piperazines was synthesized and their effect of reducing serum cholesterol and triglyceride levels in the rat was evaluated.A systematic exploration of the structure-activity relationships led to the synthesis of (R,S)-(3,5-dimethylisoxazol-4-yl)<4-(1-methylethyl)phenyl>(4-methylpiperazin-1-yl)methane dihydrochloride (M and B 31426), which had potent activity in lowering serum lipid levels at a daily oral dose of 2 mg/kg and was 100 times more potent than clofibrate.