TOTAL SYNTHESIS OF (-)-SWAINSONINE, AN α-D-MANNOSIDASE INHIBITOR ISOLATED FROM Swainsona canescens

DOI: 10.1016/0008-6215(85)85186-7

Source and publish data:

Carbohydrate Research p. 67 - 76 (1985)

Update date:2022-07-30

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Authors:

Suami, Tetsuo

Tadano, Kin-Ichi

Iimura, Youichi

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Article abstract of DOI:10.1016/0008-6215(85)85186-7

A newly isolated alkaloidal toxin, (-)-swainsonine <(1S,2R,8R,8aR)-1,2,8-trihydroxyoctahydroindolizine>, which exhibits an α-D-mannosidase inhibitory activity, has been synthesised stereoselectively in 15 steps starting from methyl 3-acetamido-2,4,6-tri-O-acetyl-3-deoxy-α-D-mannopyranoside.

Full text of DOI:10.1016/0008-6215(85)85186-7

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