Benzisoxazolones: Antimicrobial and antileukemic activity

DOI: 10.1021/jm00375a022

Source and publish data:

Journal of Medicinal Chemistry p. 1212 - 1215 (1984)

Update date:2022-08-05

Topics:

Authors:

Wierenga

Evans Evans

Zurenko Zurenko

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Article abstract of DOI:10.1021/jm00375a022

An unusual acid-mediated rearrangement of o-nitrostyrene oxide afforded 1-(hydroxymethyl)-2,1-benzisoxazol-3(1H)-one which exhibited broad-spectrum antimicrobial and cytotoxic activity. A number of analogues were prepared by employing a modified zinc-redu

Full text of DOI:10.1021/jm00375a022

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