Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors

Article abstract of DOI:10.1016/j.bmcl.2006.06.065

A novel class of non-nucleoside HCV NS5B polymerase inhibitors has been identified from screening. A co-crystal structure revealed an allosteric binding site in the protein that required a unique conformational change to accommodate inhibitor binding. Her