Total synthesis of 16-membered tetraene macrolide hygrolidin

DOI: 10.1016/S0040-4039(96)02133-8

Source and publish data:

Tetrahedron Letters p. 9077 - 9080 (1996)

Update date:2022-07-30

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Authors:

Makino, Kazuishi

Nakajima, Noriyuki

Hashimoto, Shun-Ichi

Yonemitsu, Osamu

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Article abstract of DOI:10.1016/S0040-4039(96)02133-8

The first total synthesis of 16-membered tetraene macrolide antibiotic hygrolidin, a potent and relatively specific inhibitor of the vacuolar ATPases, has been achieved, incorporating macrolactonization by the modified Yamaguchi method and fragment assemb

Full text of DOI:10.1016/S0040-4039(96)02133-8

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