Tetrahedron Letters p. 9077 - 9080 (1996)
Update date:2022-07-30
Topics:
Makino, Kazuishi
Nakajima, Noriyuki
Hashimoto, Shun-Ichi
Yonemitsu, Osamu
The first total synthesis of 16-membered tetraene macrolide antibiotic hygrolidin, a potent and relatively specific inhibitor of the vacuolar ATPases, has been achieved, incorporating macrolactonization by the modified Yamaguchi method and fragment assemb
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