Preparation of functionalized α-chloromethyl ketones using Rieke zinc

Article abstract of DOI:10.1080/00397919508011467

The cross-coupling reaction of highly functionalized organozinc reagents with chloroacetyl chloride mediated by copper allows for the easy preparation of functionalized α-chloromethyl ketones in excellent yields.

Full text of DOI:10.1080/00397919508011467

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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Preparation of Functionalized
α-Chloromethyl Ketones Using
Rieke Zinc
Reuben D. Rieke a , Jeff D. Brown a & Xiaoming Wu a
a Department of Chemistry, University of Nebraska-
Lincoln, Lincoln, Nebraska, 68588-0304
Published online: 23 Sep 2006.
To cite this article: Reuben D. Rieke , Jeff D. Brown & Xiaoming Wu (1995)
Preparation of Functionalized α-Chloromethyl Ketones Using Rieke Zinc, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 25:23, 3923-3930, DOI: 10.1080/00397919508011467
To link to this article: http://dx.doi.org/10.1080/00397919508011467
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