ACETALS OF LACTAMS AND ACID AMIDES. 41. ENAMINO AMIDES IN THE SYNTHESIS OF PYRIMIDINE DERIVATIVES

Article abstract of DOI:10.1007/BF00513864

The reaction of α-cyano-β-dimethylaminomethyleneacrylamide with arylamines was used to synthesize α-cyano-β-arylaminoacrylamides, which react readily with dimethylformamide diethylacetal to give the corresponding N-dimethylaminomethylene derivatives.The latter undergo cyclization to 1-aryl-5-cyano-4-pyrimidinones when they are heated in dimethylformamide or acetic anhydride and to pyrimido<5,4-c>quinolone derivatives when they are heated in glacial acetic acid.