Tetrahedron p. 621 - 626 (1984)
Update date:2022-07-29
Topics: Catalyst Efficient Synthesis Experimental procedure Friedel-Crafts reaction
Gill, Melvyn
2-(Trimethylsilyl)benzofuran, available quantitatively from benzofuran itself, reacts rapidly with primary, secondary, and tertiary aliphatic carboxylic acid chlorides in the presence of titanium(IV) chloride at low temperature to afford the corresponding 2-acylbenzofurans in excellent yields.This approach offers significant synthetic advantage over existing routes to the title compounds.
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