Lanthanide triflate-catalyzed preparation of β,β- difluorohomopropargyl alcohols in aqueous media. Application to the synthesis of 4,4-difluoroisochromans

Article abstract of DOI:10.1021/jo0614588

An indium-mediated Barbier-type reaction of difluoropropargyl bromide with several aldehydes in aqueous media was enhanced by a catalytic amount of a lanthanide triflate (5 mol %). The reaction gave the corresponding β,β-difluorohomopropargyl alcohols wit