Catalytic reductive N-alkylation of anilines. Application to the synthesis of N-aryl aminoacid precursors

Article abstract of DOI:10.1016/0040-4020(96)00503-0

Different anilines have been monoalkylated by reductive alkylation using ketones and α-ketoesters as alkylating agents with good isolated yields. This provided access to aminoacid derivatives. Diastereoselective experiments were also performed.