DESULPHURATIVE APPROACHES TO PENEM ANTIBIOTICS. IV. BROMINATION OF 3-METHYL-2-THIACEPHEMS, A NOVEL ENTRY IN THE SYNTHESIS OF POTENT ANTIMICROBIAL AGENTS

DOI: 10.1016/S0040-4039(00)88159-9

Source and publish data:

Tetrahedron Letters p. 3283 - 3286 (1983)

Update date:2022-07-29

Topics:

Authors:

Perrone, Ettore

Alpegiani, Marco

Bedeschi, Angelo

Giudici, Franco

Foglio, Maurizio

Franceschi, Giovanni

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Article abstract of DOI:10.1016/S0040-4039(00)88159-9

The 3-methyl group in 2-thiacephem-4-carboxylates can be brominated in good yield, thus providing access to a series of highly active penem antibiotics.

Full text of DOI:10.1016/S0040-4039(00)88159-9

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