Sequence-specific nucleic acid damage induced by peptide nucleic acid conjugates that can be enzyme-activated

Article abstract of DOI:10.1002/anie.200601681

Recruitment drive: A 12 mer peptide nucleic acid(PNA)-flavin conjugate is prepared. When the PNA moiety is hybridized to its complementary sequence in a 25 mer oligo-2′-deoxyribonucleotide, the flavin moiety can recruit an NADPH:flavin oxidoreductase. This complex allows the activation of molecular oxygen in the presence of NADH and the selective oxidation of the oligonucleotide target (see scheme). (Figure Presented)