Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure-activity relationship elucidation

DOI: 10.1016/j.bmcl.2007.10.080

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 256 - 261 (2008)

Update date:2022-07-29

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Authors:

Peters, Jens-Uwe

Luebbers, Thomas

Alanine, Alexander

Kolczewski, Sabine

Blasco, Francesca

Steward, Lucinda

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Article abstract of DOI:10.1016/j.bmcl.2007.10.080

The optimisation of affinity and selectivity in a novel series of dual 5-HT_5A/5-HT₇ receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines with low nanomolar affinities were identified.

Full text of DOI:10.1016/j.bmcl.2007.10.080

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