Bioorganic and Medicinal Chemistry Letters p. 2812 - 2818 (2005)
Update date:2022-08-02
Topics:
Pfefferkorn, Jeffrey A.
Nugent, Richard
Gross, Rebecca J.
Greene, Meredith
Mitchell, Mark A.
Reding, Matthew T.
Funk, Lee A.
Anderson, Rebecca
Wells, Peter A.
Shelly, John A.
Anstadt, Robert
Finzel, Barry C.
Harris, Melissa S.
Kilkuskie, Robert E.
Kopta, Laurice A.
Schwende, Francis J.
A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.
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